Outline of Ideas


  • I. Introduce real world mystery (CSI) that can be solved using DNA technology
  • II. DNA: The Hereditary Molecule
    • a. DNA is Genetic Material
      • i. Explain that Mendel inferred the existence of genetic material
      • ii. Describe experiment that proved DNA is genetic material
    • b. DNA Structure
      • i. Describe nucleotide structure using Powerpoint slides
      • ii. Describe DNA structure using Powerpoint slides
      • iii. Build an edible model of DNA
    • c. DNA Replication
      • i. Describe process of DNA replication using Powerpoint slides
      • ii. Use edible DNA model to model the process of DNA replication
  • III. From DNA to Protein
    • a. RNA Structure
      • Describe RNA structure by comparing it to DNA using Powerpoint slides
    • b. Provide overview of Central Dogma using Powerpoint slides
    • c. Transcription: DNA to mRNA
      • i. Use edible DNA models to model the process of mRNA transcription
    • d. Describe mRNA traveling from nucleus to the cytoplasm using Powerpoint slides
    • e. Describe splicing of mRNA using Powerpoint slides
    • f. Translation: mRNA to Protein
      • i. Overview of translation using Powerpoint slides
      • ii. Describe tRNA Structure using Powerpoint slides
      • iii. Describe genetic code using Powerpoint slides
      • iv. Use edible mRNA model to model the process of mRNA translation
  • IV. Genetic Changes
    • a. Introduce images of mutations using Powerpoint slides
    • b. Describe three types of mutations and their consequences
    • c. Do activity in which students transcribe and translate mutated sequences
    • d. Describe the major types of mutagens using Powerpoint slides
    • e. Explain DNA repair mechanisms
    • f. Explain different consequences of reproductive and somatic cell mutations using Powerpoint slides
  • V. From DNA to Disease
    • a. Explore the connection between DNA sequences and disease using BLAST
    • b. Engage in using an authentic bioinformatics tool identify the disease a patient is suffering based on an mRNA sequence found in a tissue
  • VI. DNA Fingerprinting to Solve a Mystery
    • a. Stage a murder mystery
    • b. Turn classroom in a forensics lab, in which a DNA fingerprinting simulation is done to solve the murder mystery

Quist and Holoweski - Genes and DNA Unit Design

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